Figure 6.
Epileptiform events fail to develop over time in mice treated with doxycycline until age 7 weeks. A, Measured rates of epileptiform events in untreated (red) and doxycycline treated (green) mice by age at time of measurement. Connected points indicate observations from the same mouse. All doxycycline-treated mice failed to develop events over the measured time period. Note that the mice represented in this figure are a small subset of all measured mice, and we do not intend to claim that the time courses followed here are representative of all mice developing events. B, C, and D refer to the measurements corresponding to the figure panels at right. B–D, Example traces and prominence versus width plots for an example untreated mouse showing development of events between 11 and 14 weeks.