Table 1.
Activating and inhibitory receptors on NK cells.
| Type | Receptors | Ligands | Species |
|---|---|---|---|
| Activating receptors | NKG2D | Mouse: Rae1a-e, MULT-1, H60 | Mouse/human |
| Human: MIC-A/-B, ULBP1–4 | |||
| CD94-NKG2C | Mouse: Qa1b | Mouse/human | |
| Human: HLA-E | |||
| Ly49D | Mouse: H-2Dd | Mouse | |
| Ly49H | Mouse: m157 of MCMV | Mouse | |
| KIR2DL4 | Human: HLA-G | Human | |
| KIR2DS1 | Human: HLA-C2 | Human | |
| KIR2DS2 | Human: HLA-C1 | Human | |
| KIR2DS3 | Unknown | Human | |
| KIR2DS4 | Human: HLA-A11 | Human | |
| KIR2DS5 | Unknown | Human | |
| KIR3DS1 | Human: HLA-Bw4 | Human | |
| NKp30 | Human: B7H6, BAT3, pp65 of HCMV, PfEMP1 of Plasmodium falciparum, viral HA | Human | |
| NKp46 | Heparin, viral HA and HN | Mouse/human | |
| NKp44 | Viral HA and HN, PCNA, proteoglycans | Human | |
| NKR-P1C | Mouse | ||
| NKR-P1F | Mouse: Clr-g, Clr-c | Mouse | |
| NKR-P1G | Mouse: Clr-g, Clr-f | Mouse | |
| DNAM-1 | Mouse and human: CD112, CD155 | Mouse/human | |
| Inhibitory receptors | Ly49A | Mouse: H-2Db,d,k,p, H-2M3 | Mouse |
| Ly49C | Mouse: H-2Db,d,k H-2Kb,d,k m157 | Mouse | |
| Ly49I | Mouse: H-2kb,s,q,v | Mouse | |
| Ly49P | Mouse: H-2Dd,k | Mouse | |
| KIR2DL1 | Human: HLA-C2 | Human | |
| KIR2DL2 | Human: HLA-C1 | Human | |
| KIR2DL3 | Human: HLA-C1 | Human | |
| KIR3DL1 | Human: HLA-Bw4 | Human | |
| KIR3DL2 | Human: HLA-A3,-A11 | Human | |
| NKR-P1A | Human: LLTI | Human | |
| NKR-P1B | Mouse: Clr-b | Mouse | |
| NKR-P1D | |||
| CD94-NKG2A | Mouse: Qa1b | Mouse/human | |
| Human: HLA-E | |||
| ILT2 (CD85j) | Human: HLA-A, -B, -C, HLA-G1, HCMV UL18 | Human | |
| CD244(2B4) | Mouse and human: CD48 | Mouse/human | |