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. 2017 Sep 7;10:286. doi: 10.3389/fnmol.2017.00286

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Copyright © 2017 Sun, Yang, Shao, Sun, Gu, Wang, Jiang, Qu, Sun and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apoptosis induced by ER stress in the hippocampus. (A) Representative immunoblot for cleaved caspase-12, cleaved caspase-3 and GAPDH. (B) Relative density analysis of the cleaved caspase-12 and cleaved caspase-3 protein bands. The relative density is expressed as the ratio (cleaved caspase-12/GAPDH; cleaved caspase-3/GAPDH; n = 5). (C) Photomicrographs of TUNEL-positive cells in the hippocampal CA1 of all treated groups (magnification 200×). Scale bar = 100 μm. (D) Hippocampal CA1 neurons apopotosis index in each group (n = 8). Data were expressed as mean ± SD. *P < 0.05, **P < 0.01 vs. control group. ^#P < 0.05, ^##P < 0.01.