Figure 5.
Panels A to E show the effect of acute systemic administration of LY2444296 (0, 3 mg/kg) on A) the time spent in the open arms, B) the latency to the first entrance in an open arm and C) the total number of entries in the closed arms in an 5-min EPM test, as well as D) the immobility, E) the latency to show immobility in a 5-min FST, performed in rats tested 30 h after their last extended access cocaine self-administration session (n= 9–11/group). All panels show the Mean ±SEM. *** p< 0.001, ** p< 0.01, * p< 0.05 versus vehicle-injected cocaine rats (Student’s t test). Panel F shows the Mean ±SEM of serum corticosterone concentration measured in rats pre-treated with acute systemic administration of LY2444296 (0, 3 mg/kg; n= 4/group) 30 h after their last extended access cocaine self-administration session, with no exposure to FST or EPM. # p<0.05 versus vehicle-injected cocaine exposed rats (LSD test).