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. 2017 Aug 30;7:10071. doi: 10.1038/s41598-017-09520-7

Figure 2.

Figure 2

Oral celecoxib treatment reduced TAF and disrupted tumor fibronectin bundles demonstrated by immunofluorescence staining. (A) TAF expression (green) in the tumor tissues with or without celecoxib treatment and (B) the corresponding percentage of TAF (FAPα+) in the tumor tissue cells per field (n = 18). The TAF was labeled by FAPα antibody. (C) The fibronectin expression (green) in the tumor tissue with or without celecoxib treatment and (D) the corresponding fluorescence intensity of fibronectin per field (n = 18). The oral dose of celecoxib was 200 mg/kg/day for 14 days. The bar indicates 100 μm, and the nuclei were stained with Hoechst 33342 (blue). ***P < 0.0001 vs. the control group.