Table 2.
Baseline AD-related phenotypic data and cognitive descriptive statistics for clinical classifications across the cohort. All data is presented as means ± standard deviations. CN, cognitive normal; MCI, Mild cognitively impaired; AD, Alzheimer’s disease; VEM, Verbal Episodic Memory; ViEM, Visual Episodic Memory; EF, Executive Function; LANG, Language; GLOBAL, Global cognitive composite; HV, Intracranial volume corrected Hippocampal Volume; NAB, Neocortical Amyloid Burden; SUVR-BeCKeT, a transformation of native SUVR into PiB-like SUVR.
| CN | MCI | AD | P value | |
|---|---|---|---|---|
| Cognitive Composites | ||||
| VEM | 0.032 ± 1.20 (n = 891) | −2.69 ± 1.49 (n = 146) | −3.93 ± 1.70 (n = 152) | <0.001 |
| ViEM | −0.010 ± 1.31 (n = 900) | −2.02 ± 1.39 (n = 152) | −4.42 ± 1.36 (n = 166) | <0.001 |
| EF | 0.006 ± 1.08 (n = 883) | −1.24 ± 1.23 (n = 146) | −3.37 ± 1.89 (n = 139) | <0.001 |
| LANG | 0.015 ± 0.72 (n = 887) | −1.26 ± 0.90 (n = 153) | −3.50 ± 1.32 (n = 174) | <0.001 |
| GLOBAL | 0.026 ± 1.17 (n = 889) | −3.07 ± 1.68 (n = 146) | −6.37 ± 2.14 (n = 151) | <0.001 |
| Neuroimaging/CSF Biomarkers | ||||
| HV (cm3) | 2.93 ± 0.27 (n = 229) | 2.62 ± 0.42 (n = 52) | 2.39 ± 0.38 (n = 38) | <0.001 |
| NAB (SUVR-BeCKeT) | 1.38 ± 0.40 (n = 262) | 1.86 ± 0.53 (n = 69) | 2.11 ± 0.50 (n = 48) | <0.001 |
| CSF Aβ42 | 681.2 ± 201.9 (n = 36) | 590.3 ± 229.7 (n = 14) | 496.9 ± 243.5 (n = 16) | 0.022 |
| CSF T-tau | 330.6 ± 236.8 (n = 36) | 512.0 ± 321.0 (n = 14) | 587.5 ± 235.4 (n = 16) | 0.003 |
| CSF P-tau | 58.2 ± 29.1 (n = 36) | 75.4 ± 34.9 (n = 14) | 79.6 ± 23.7 (n = 16) | 0.031 |
| CSF Aβ42:T-tau | 2.72 ± 1.40 (n = 36) | 1.77 ± 1.30 (n = 14) | 1.01 ± 0.79 (n = 16) | <0.001 |
| CSF Aβ42:P-tau | 13.82 ± 6.12 (n = 36) | 10.35 ± 7.04 (n = 14) | 6.85 ± 4.46 (n = 16) | 0.001 |