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. Author manuscript; available in PMC: 2017 Aug 28.

Published in final edited form as: Clin Cancer Res. 2016 May 16;22(22):5487–5496. doi: 10.1158/1078-0432.CCR-16-0127

Table 2.

Cox regression analysis.

Variable	Categories	Combined discovery & confirmation cohorts (n=346)		Validation cohort (n=166)		All patients (n=512)
Variable	Categories	Hazard ratio [95% CI]	Wald test P-value	Hazard ratio [95% CI]	Wald test P-value	Hazard ratio [95% CI]	Wald test P-value
Visceral involvement	Unresectable stage III, distant lymph nodes/soft tissue, lung	1.0	<0.001	1.0	0.008	1.0	<0.001
Visceral involvement	Other visceral involvement	2.5[1.5;4.1]	<0.001	3.5[1.4;8.9]	0.008	2.7[1.8;4.2]	<0.001
LDH-ratio	≤2.5	1.0	<0.001	1.0	<0.001	1.0	<0.001
LDH-ratio	>2.5	2.5 [1.7;3.6]	<0.001	6.1[3.1;12.3]	<0.001	2.8 [2.0;3.9]	<0.001
Relative lymphocyte count	<17.5%	1.9 [1.3;2.8]	<0.001	2.4 [1.4;4.4]	0.003	2.0 [1.5;2.8]	<0.001
Relative lymphocyte count	≥17.5%	1.0	<0.001	1.0	0.003	1.0	<0.001
Relative eosinophil count	<1.5%	2.2 [1.5;3.1]	<0.001	2.2 [1.2;3.9]	0.006	2.0 [1.5;2.8]	<0.001
Relative eosinophil count	≥1.5%	1.0	<0.001	1.0	0.006	1.0	<0.001

LDH: lactate dehydrogenase; CI: confidence interval.