Figure 4. Simulated cell shape index(A) and cell tracking.
(A) Box plot of cell shape index from simulations of single cell migration with varied substrate curvature. Radius of substrate R0 equals ± 50, ±70, ±90, ±110 μm with yellow for concave and cyan for convex. (B) Simulated cell tracks from 3 hours’ cell migration on curved substrate, projected on the xy plane: blue line for convex substrate, dashed green for concave substrate, magenta for flat substrate. Insert shows zoomed in cell tracks on a flat surface. (C) Angular distribution of instantaneous cell velocity on convex substrate with low frequency details (left) and the whole distribution (upper right). (D) Angular distribution of instantaneous cell velocity on concave substrate with low frequency details (left) and the whole distribution (upper right).