Table 1.
Patient Characteristics
| Characteristics | Number | Percent |
|---|---|---|
| Total Enrolled | 18 | 100 |
| Age Median (Range) | 66 (49–87) years | |
| Male sex | 11 | 61 |
| ECOG Performance Status | ||
| 1 | 13 | 72 |
| 2 | 3 | 17 |
| 3 | 2 | 11 |
| Histology: Large B-cell lymphoma (PCNSL) | 18 | 100 |
| Untreated PCNSL | 5 | 28 |
| Previously treated PCNSL | 13 | 72 |
| Median (range) regimens | 2 (1–6) | |
| Treatment refractory | 11 | 85 |
| Prior methotrexate | 13 | 100 |
| Prior rituximab | 12 | 92 |
| Prior cranial radiation | 4 | 31 |
| Autologous Transplant | 4 | 31 |
| Disease sites | ||
| CSF + Flow cytometry | 9 | 50 |
| Intraocular | 3 | 11 |
| Deep brain lesions | 13 | 72 |
| Peripheral Disease | 3 | 11 |
| Elevated LDH | 10 | 56 |
| IELSG risk groups | ||
| 0–1 | 3 | 17 |
| 2–3 | 7 | 39 |
| 4–5 | 8 | 44 |