Fig 1.
Representative photomicrographs of urinary bladder cancer biopsy specimens from patients, illustrating immunohistochemical staining for programmed cell death ligand-1 (PD-L1) on tumor cells (TC) and tumor-infiltrating immune cells (IC). (A) Tumor biopsy with ≥ 25% TC and ≥ 25% IC (TC-positive/IC-positive) PD-L1 staining; (B) < 25% TC and ≥ 25% IC (TC-negative/IC-positive) PD-L1 staining; (C) ≥ 25% TC and < 25% IC (TC-positive/IC-negative) PD-L1 staining; and (D) < 25% TC and < 25% IC (TC-negative/IC-negative) PD-L1 staining.