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a, One protomer in CNTNWN149S,F366A adopts an outward-facing conformation (*). Scaffold domain (grey); TM1, TM7, TM8 (teal); TM2, TM4, TM5 (orange); HP1 (red); HP2 (blue). b–c, Inward- (left) and outward-facing (right) protomers from the trimerization axis (b) and 90 degrees rotated (c). The ~12-Å movement of the transport domain (blue) shifts the substrate-binding sites (red circle) past TM6.
