TABLE 3.
Results from Statistical Analysis
| Disease | Variants, No. (%) | Patients, No. | Variants, No. (%) | Controls, No. | p | Odds Ratio [95% CI] |
|---|---|---|---|---|---|---|
| ALS | 31 (0.48) | 6,471 | 3 (0.04) | 7,668 | 9.3 × 10−6 | 9.22 (3.05–27.89) |
| PD | 14 (0.45) | 3,146 | 3 (0.05) | 5,631 | 4.3 × 10−5 | 6.74 (2.10–21.68) |
Exact p values were computed by permutation testing, randomizing case–control status of individuals of a single country (100,000,000 permutations were performed). All p values are 1-sided, testing the specific hypothesis that the presence of rare variants increases risk of ALS or PD. For the analyses in PD, we included control subjects only from countries from which PD cases were available.
ALS = amyotrophic lateral sclerosis; CI = confidence interval; PD = Parkinson disease;