. 2017 Aug 15;8:1539. doi: 10.3389/fmicb.2017.01539

Table 1.

Antimycobacterial activities (μM) of top NTM hits identified in the Pathogen Box screen.

Compound ID	M. tuberculosis			M. abscessus			M. avium			Chemical class^*	Possible target^*
	MIC₅₀	MIC₉₀	Reported MIC^b	MIC₅₀	MIC₉₀	Fold kill at MIC₉₀	MIC₅₀	MIC₉₀	Fold kill at MIC₉₀
MMV688756	<0.2	1.2	1.2	4.2	25	NK	0.4	4	NK	Oxazolidinone	23S rRNA
MMV688327^a	0.5	2	0.3	3.8	13	NK	4	35	NK	Oxazolidinone	23S rRNA
MMV688508	<0.2	0.3	0.4	2.2	12	NK	0.6	8	NK	Oxazolidinone	23S rRNA
MMV687146	<0.2	<0.2	<0.024	0.8	2	100	3	9	NK	Indolecarboxamide	MmpL3
MMV688846^a	0.2	0.6	0.4	0.7	1.5	10	20	>50	NK	Piperidinol	MmpL3
MMV687730	<0.2	<0.2	0.05	4	8.5	10	5	22	NK	Benzimidazole	FtsZ
MMV687812^a	<0.2	2.2	1.2	6	12^∧	NK^∧	25	>50	NK	Aminopyrazinamide	GyrB
MMV675968	<0.2	4	ND	10.5	35	NK	0.2	3	NK	Diaminopyrimidine	DHFR
MMV688845	<0.2	1.7	1.2	1.5	7	10	0.6	3	NK	Phenylalaninamide	RNA polymerase
MMV688844^a	0.2	2.8	0.4	4.5	11	100	2	6^#	NK^#	Piperidine	ABC transporter
clarithromycin	ND	ND	ND	<0.2	0.5	NK	<0.2	0.6	NK	Macrolide	23S rRNA

“M. abscessus-specific” hits according to primary screen cut-off.

MIC in M. tuberculosis as reported by MMV (website http://www.pathogenbox.org/).

^∧

MMV687812, for M. abscessus 80% growth inhibition was achieved at 12 μM, MIC₉₀ could not be reached up to 50 μM.

MMV688844, for M. avium 80% growth inhibition was achieved at 6 μM, MIC₉₀ could not be reached up to 50 μM.

See discussion section for references.

MIC₅₀, MIC₉₀ refers to the compound concentration that inhibits 50 and 90% of bacterial growth, respectively.

NK, “no kill,” i.e., CFU reduction < 10-fold at MIC₉₀; ND, not determined.