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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Nanomedicine. 2017 Apr 9;13(6):2049–2059. doi: 10.1016/j.nano.2017.03.015

Figure 3. Fullerol alleviated mechanical hypersensitivity induced by implanted disc tissue.

Figure 3

Paw withdrawal thresholds were recorded prior to surgery and every other day up to 21 days post-operatively (A. Right paws. B. left paws). Fullerol exhibited a profound alleviation of mechanical hypersensitivity. Ten µM fullerol caused a significant alleviation of mechanical hyperalgesia back to baseline on POD6 (* p<0.01, n=7). Fullerol at 100 µM showed alleviation on POD2 (#p<0.05). There is no significant difference between 10 and 100 µM (p>0.05). C. Decreased pro-inflammatory cytokine mRNA in DRGs of 10 µM fullerol treated group but not in 100 µM fullerol group (*, p<0.05) as compared with PBS group on POD21.