Table 1.
Cx43 expression and invasive capacity of gliomas maintained in nude mice
| Controls | CBX | |||||
| Tumor | Tumor§ | Cx43 | (S-S0)/S0 | Cells/mm perimeter | (S-S0)/S0 | Cells/mm perimeter |
| T1 | TG-4-GEN | +++ | 1.15 ± 0.23 | 77 ± 9.4 | 1.05 ± 0.11 | 68 ± 5.6 |
| T2 | TG-1-HAM | +++ | 0.56 ± 0.05 | 81 ± 9.4 | 0.29 ± 0.08 *** | 50 ± 7.5 * |
| T3 | TG-7-ROM | + | 0a | - | 0a | - |
| T4 | TG-14-RAV | +++ | 1.11 ± 0.08 | 73 ± 6.7 | 0.71 ± 0.04 ** | 54 ± 4.7 * |
| T6 | TG-5-RAI | +/- | 0a | - | 0a | - |
| T7 | TG-14-CHA | +++ | 0.45 ± 0.08 | 48 ± 4.2 | 0.22 ± 0.01 *** | 35 ± 4.4 * |
| T8 | TG-20-THO | +/- | 0a | - | 0a | - |
a, cut off : a tumor which exhibited less than 15 migrating cells distance of migration, if any, less than 50 μm, was considered non invasive.
§ Xenograft tumor nomenclature as originally described by Leuraud et al (2003).
n = 7–10 per group and condition. ***, p < 0.001. **, p < 0.01, *, p < 0.05