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. Author manuscript; available in PMC: 2017 Dec 7.
Published in final edited form as: Nature. 2017 Jun 7;546(7659):498–503. doi: 10.1038/nature22341

Figure 3. CD47 and macropinocytosis enhance iExosomes uptake and therapeutic efficacy.

Figure 3

(A) Panc-1 orthotopic tumor growth, n=3 mice per group. (B) KPC689 orthotopic tumor growth, n=8 mice per group. (C) Kaplan-Meier curve, KPC689 orthotopic tumor bearing mice, Log-rank Mantel-Cox test, n=8 mice per group. (D) Confocal micrographs (scale bar: 100μm) of increased (preferential) entry of labeled exosomes into tumor tissue. (E) Macropinocytic uptake in Panc-1 or BxPC-3 cells, unpaired two-tailed t test. (F–G) Macropinocytic and exosomes uptake in BxPC-3 (unpaired two-tailed t test, F) or Panc-1 (one-way ANOVA comparing treated groups to non-treated group (0 μM EIPA, G) cells treated with vehicle (DMSO) or EIPA at the indicated concentrations (H) Macropinocytic and liposomes uptake, unpaired two-tailed t test. E, G, H: 5 distinct wells, F: 3 distinct wells. In E–H, scale bar: 50μm. The data is presented as the mean ± SEM. * p<0.05, ** p< 0.01, *** p<0.001, **** p<0.0001, ns: not significant. See accompanying source data.