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. 2001 Jul 31;98(16):8955–8960. doi: 10.1073/pnas.171259298

Table 1.

Genes that increase under shear stress detected by DNA microarray analysis

Group* Gene Ratio (SS/Cont)
Antioxidants Cytochrome P450 1B1 6 h 7.55  ± 1.28
AA448157 24 h 9.70  ± 2.71
Cytochrome P450 1A1 6 h 3.90  ± 0.48
AA418907 24 h 11.15  ± 3.75
Heme oxygenase-1 6 h 3.08  ± 0.84
T71606 24 h 1.78  ± 0.18
NAD(P)H:quinone oxidoreductase (NQO1) 6 h 1.28  ± 0.12
AA458634 24 h 2.09  ± 0.32
Proliferation/differentiation Zinc finger protein EZF/GKLF 6 h 4.56  ± 0.69
H45668 24 h 2.78  ± 0.54
Receptor tyrosine phosphatase 6 h 3.73  ± 0.77
AA486403 24 h 1.82  ± 0.05
TGF-β-stimulated clone 22 (TSC-22) 6 h 2.18  ± 0.23
AA664389 24 h 2.18  ± 0.25
Tyrosine kinase receptor precursor 6 h 2.31  ± 0.36
TIE-2 H02848 24 h 1.80  ± 0.48
Tyrosine kinase HTK 6 h 1.40  ± 0.05
T51849 24 h 2.09  ± 0.79
E2F transcription factor 5, p130 binding 6 h 2.05  ± 0.71
AA455521 24 h 1.56  ± 0.64
Human orphaned G protein coupled receptor 6 h 2.39  ± 1.17
N53172 24 h 1.13  ± 0.31
Glycyl tRNA synthetase 6 h 1.97  ± 0.56
AA629909 24 h 1.08  ± 0.19
Jagged 1 (Human HJ1) 6 h 2.22  ± 0.37
R70685 24 h 1.82  ± 0.51
Vascular tone Argininosuccinate synthetase 6 h 2.41  ± 0.21
AA676466 24 h 3.04  ± 0.88
α-Galactosidase A precursor 6 h 1.42  ± 0.02
AA251784 24 h 2.56  ± 0.23
Vasoactive intestinal polypeptide receptor 6 h 1.39  ± 0.20
precursor (VIPR1) H73241 24 h 2.13  ± 0.28
PGHS-2 6 h 2.20  ± 0.45
AA644211 24 h 0.91  ± 0.16
ECM/cytoskeleton Elastin 6 h 2.93  ± 0.42
AA459308 24 h 2.26  ± 0.59
Connexin 37 6 h 2.45  ± 0.88
H44032 24 h 1.48  ± 0.38
α-Spectrin 6 h 1.76  ± 0.17
T60117 24 h 1.99  ± 0.51
Galectin 3 6 h 1.22  ± 0.09
AA630328 24 h 2.16  ± 0.56
Immune/inflammation Podocalyxin-like protein 6 h 3.37  ± 0.55
N64508 24 h 1.77  ± 0.21
CD34 6 h 1.70  ± 0.20
AA043438 24 h 2.41  ± 0.22
IL-1 receptor, type 1 precursor 6 h 1.51  ± 0.38
AA464526 24 h 2.22  ± 0.18
Leukocyte elastase inhibitor 6 h 1.06  ± 0.11
AA486275 24 h 2.11  ± 0.58
Transcription factor Glucocorticoid-induced leucine zipper protein 6 h 3.35  ± 0.70
AA775091 24 h 3.28  ± 0.79
Transport systems Human prostaglandin transporter 6 h 3.33  ± 1.05
AA037014 24 h 2.49  ± 0.19
Heat shock protein 70 6 h 2.08  ± 0.31
AA629567 24 h 0.76  ± 0.09
Chromogranin A 6 h 1.05  ± 0.17
R36264 24 h 2.07  ± 0.83
Protein modification Paired basic amino acid cleaving system 4 6 h 1.74  ± 0.30
AA251457 24 h 2.44  ± 0.21
RNA degradation RNase A family, 1 6 h 0.91  ± 0.18
AA485893 24 h 2.01  ± 0.06
Thrombosis S100 calcium binding protein A10 6 h 1.27  ± 0.23
AA444051 24 h 1.96  ± 0.32
*

Genes were grouped based on function. Many genes can be assigned to more than one group (e.g., transcription factors).