Table 3.
CAR targets for the treatment of solid malignancies
| Target | CAR structure | Malignancy | Institution | Reference |
|---|---|---|---|---|
| PSMA | CD3ζ and CD28 | Prostate cancer | MSKCC | NCT01140373 (REF. 76) |
| Roger Williams | NCT00664196 (REF. 78) | |||
| Mesothelin | CD3 and 4-1BB | Malignant pleural mesothelioma | UPenn | NCT01355965 (REF. 81) |
| Pancreatic cancer | UPenn | NCT02465983 (REF. 156) | ||
| Metastatic pancreatic (ductal) adenocarcinoma, epithelial ovarian cancer and malignant epithelial pleural mesothelioma | UPenn | NCT02159716 (REF. 84) | ||
| CD3ζ and CD28 | Mesothelioma and malignant pleural disease | MSKCC | NCT02414269 (REF. 85) | |
| CD3ζ, CD28 and 4-1BB | Mesothelioma, pancreatic and ovarian cancer | NCI | NCT01583686 (REF. 86) | |
| FAP | CD3ζ and CD28 | Mesothelioma | University of Zurich (Switzerland) | NCT01722149 (REF. 90) |
| EGFRvIII | CD3ζ and 4-1BB | Glioma | UPenn | NCT02209376 (REF. 95) |
| CD3ζ, CD28 and 4-1BB | Glioma | NCI | NCT01454596 (REF. 97) | |
| EGFR | Unknown | Malignant glioma | Renji Hospital (China) | NCT02331693 (REF. 98) |
| CEA | CD3ζ and CD28 | Liver metastases | Roger Williams | NCT02146466 (REF. 100) |
| Unknown | Lung, colorectal, gastric, breast and pancreatic cancer | Southwest Hospital (China) | NCT02349724 (REF. 103) | |
| CD171 | CD3ζ and 4-1BB or CD3ζ, CD28 and 4-1BB | Neuroblastoma | Seattle Children’s | NCT02311621 (REF. 106) |
| GD2 | CD3ζ, OX40, CD28 | Neuroblastoma, osteosarcoma and melanoma | NCI | NCT02107963 (REF. 112) |
| Neuroblastoma | Baylor | NCT01822652 (REF. 114) | ||
| CD3ζ, Ox40, CD28, virus specific | Sarcoma | Baylor | NCT01953900 (REF. 115) | |
| Glypican-3 | CD3ζ, CD28 and 4-1BB | Advanced-stage hepatocellular carcinoma | Renji Hospital (China) | NCT02395250 (REF. 117) |
| HER2 | CD3ζ and CD28 virus specific | Sarcoma | Baylor | NCT00902044 (REF. 122) |
| CD3ζ and CD28 | Glioblastoma | Baylor | NCT02442297 (REF. 126) | |
| Glioblastoma multiforme | Baylor | NCT01109095 (REF. 127) | ||
| IL-13 | RαCD3ζ and 4-1BB | Glioma | City of Hope | NCT02208362 (REF. 131) |
Baylor, Baylor College of Medicine (USA); CEA, carcinoembrionic antigen; City of Hope, City of Hope National Medical Center (USA); EGFRVII, epidermal growth factor receptor variant III; FAP, prolyl endopeptidase FAP/fibroblast activation protein alpha; MSKCC, Memorial Sloan Kettering Cancer Center (USA); NCI, National Cancer Institute (USA); PSMA, prostate-specific membrane antigen; Roger Williams, Roger Williams Medical Center (USA); Seattle Children’s, Seattle Children’s Hospital (USA); UPenn, University of Pennsylvania (USA).