Table 4.
Leave-one-out (LOO) receiver operation characteristics analyses of the pooled data.
| Combined cohort | Sensitivity (95% CI)# | Specificity (95% CI)# | AUC (P-value) | +LR | -LR | Accuracy (95% CI)# | Age-dependent∗ | Cut-off value |
|---|---|---|---|---|---|---|---|---|
| Aβ42 | 0.89 (0.79, 0.98) | 0.90 (0.82, 0.96) | 0.92 (2.90e-15) | 8.60 | 0.12 | 0.90 (0.84, 0.94) | Yes | ∗∗ |
| Tau | 0.89 (0.79, 0.98) | 0.94 (0.88, 0.99) | 0.97 (8.83e-19) | 13.76 | 0.11 | 0.92 (0.87, 0.96) | No | >25.41 |
| Aβ42/tau | 0.83 (0.72, 0.94) | 0.94 (0.88, 0.99) | 0.95 (2.11e-17) | 12.78 | 0.18 | 0.90 (0.84, 0.94) | No | >0.61 |
| Aβ42 × tau | 0.96 (0.89, 1.00) | 0.90 (0.83, 0.96) | 0.98 (3.07e-19) | 9.22 | 0.047 | 0.92 (0.87, 0.97) | No | >382.68 |
#95% CI: Lower, Upper. Abbreviations: AUC, area under curve; CI, confidence interval; +LR, positive likelihood ratio; -LR, negative likelihood ratio. ∗, The cut-off value was obtained without the LOO procedure. ∗∗, The cut-off value was a function of age.