Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Apr 15;8(26):42438–42454. doi: 10.18632/oncotarget.17124

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © 2017 Butler et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

The position of the carboxyl group in VPC-18005 (orange = carbon, blue = nitrogen, red = oxygen, yellow = sulfur) is predicted to coincide with that of a phosphate group on the DNA backbone (cyan ribbons and sticks). Thus, binding of VPC-18005 or DNA with the ERG-ETS domain is expected to be mutually exclusive. Whereas the lower portion of the VPC-18005 chemical structure occupies the same general area as the DNA, the upper portion, consisted of the isopropyl moiety and aromatic ring, extends further into the pocket (shown in grey net). The ERG-ETS protein structure is rotated −90 degree on the vertical axis, compared to those shown in Figure 2.