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A) Synthesis of the linker-drug module Mc-NC-MMAE (7). Reagents and Conditions: a) [1] 4-aminobenzyl alcohol, EDC·HCl, iPr2Net, CH2Cl2, r.t. overnight; [2] 4-nitrophenyl chloroformate, pyridine, THF, r.t. 4 h; b) MMAE·TFA, HOAt, iPr2Net, DMF, r.t. 48 h. B) size-exclusion chromatography and (C) SDS-page profiles of the F16-NC-MMAE ADC (8) in either reducing (R) and non-reducing (NR) conditions.
