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. Author manuscript; available in PMC: 2017 Jul 6.
Published in final edited form as: Nat Rev Rheumatol. 2016 Aug 19;12(10):580–592. doi: 10.1038/nrrheum.2016.136

Figure 2. The pathobiology of OA.

Figure 2

Comparison of the normal joint (left side) and the OA joint (right side), demonstrating that OA is a disease that affects the entire joint structure, including the articular cartilage, synovium, subchondral bone, joint capsule, and other components of the joint.