Fig A2.
Reclassification plots for the comparison of PREMM1,2,6 with PREMM5. The scatterplot diagrams show the added predictive value provided by the PREMM5 model in identification of (A) mutation carriers (mutation in any gene) and (B) noncarriers (no mutation in any gene) on the basis of the data from this study. (A) PREMM5 predicts mutation carriers, as shown by patients (blue circles) above the line. This is regardless of the mutation carrier status of the patient. (B) Compared with PREMM1,2,6, the extended PREMM5 model better predicts noncarriers, as shown by more patients (blue circles) below the line of identity (diagonal line). Gold circles indicate reclassification by PREMM5, in which, on average, the extended model provided lower risk estimates than PREMM1,2,6.