Figure 2.
MBSHH disease comprises two age-dependent molecular subgroups
(A) Log-normal age distributions of MBSHH-Infant (red) and MBSHH-Child disease (dark red). Patient ages at diagnosis are shown as ticks along the x-axis and are coloured by subgroup. (B) Clinicopathological and molecular disease features of MBSHH-Infant and MBSHH-Child subgroups. Residuals from χ2 tests indicate where subgroup-enrichment has occurred (darker shades of grey indicate stronger relationships); scale bar for residuals (−4 to 4) is shown. p values from χ2 tests are shown. Differentially methylated probes: Illumina probe identifiers for the top 20 most differentially methylated probes, alongside methylation status of 18 normal cerebella (pink). Each column represents one patient. (C) SHH genome-sequencing data26 was classified into methylation subgroups on the basis of age. Each column represents one patient. Amp=amplification. DN/MBEN=desmoplastic or nodular medulloblastoma with extensive nodularity. LCA=large-cell anaplastic. M+=metastatic disease. R+=residual disease.