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Therapeutic Wound Healing Targets of miR-21
Schematic diagram of miR-21 targets TIMP3 and PTEN. By inhibiting PTEN, miR-21 promotes the activation of many cell survival pathways. The Akt pathway functionality increases; thus, the mTOR pathway, for example, is heightened, which regulates protein synthesis, mitochondrial function, and glucose homeostasis. Nf-kB inhibits apoptosis and Akt inhibits BAD, which is a pro-apoptotic pathway.
