FIG. 3.
Pathology and survival of ovariectomized, hormone-treated, immunized mice following challenge with wild-type HSV-2. Mice were ovariectomized and given different combinations of hormones, as described in Materials and Methods. Three weeks after IVAG immunization with attenuated HSV-2, mice were challenged IVAG with wild-type HSV-2 (105 PFU). Vaginal pathology and survival were monitored daily. Pathology scores of each mouse in all four hormone groups over 5 days following challenge are shown. Pathology scores halfway between two numbers were given when a readout was transitional between two consecutive scores. Final survival numbers are indicated for each hormone treatment group. Each group had six to eight mice. The results shown are representative of three separate experiments.