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(A) Body weight of mice after intracerebral injection of various doses [poly(I:C), 0.25, 2.5, and 25 μg; CTB*, 2.5, 10, and 25 μg] of poly(I:C) and CTB*. Each point represents the relative ratio to initial body weight (mean ± SD [%]) of 5 mice in each day. Histopathological findings of the brains injected with 10 μg of poly(I:C) (B), 10 μg of CTB* (C), and PBS (D) at day 4 after injection (×100; H&E).
