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Dominant-negative SOCS protein prevents resistin antagonism of insulin signaling in adipocytes. 3T3-L1 adipocytes were infected with adenovirus expressing EGFP or SOCSF59D and then treated with resistin (30 ng/ml) for 2 h prior to insulin stimulation (10 nM) for 2 min, and then phosphorylation of IR and total IR protein levels were determined by immunoblot analysis.
