Figure 5.
Surface expression of GluA1 and GluA2 and total protein expression of xCT and GLT-1. Cocaine-naive rats received intra-NAc AS directed at GLT-1 (n = 5) or Ctrl oligo (n = 5). Protein expression was expressed as a percentage of the Ctrl group. A, GLT-1 antisense decreased total protein expression of GLT-1. B, The infusion of GLT-1 AS had no effect on total xCT expression. C, Surface GluA1 was not affected by GLT-1 knockdown. D, Surface GluA2 was not affected by GLT-1 knockdown. *p < 0.05 compared to Ctrl. C, Ctrl oligo; G, GLT-1 AS.