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The rise in cytosolic Ca2+ concentration in response to glucose stimulation. The cytosolic Ca2+ concentration was measured using Fura-2 acetoxymethyl ester by two-photon excitation imaging in pancreatic β cells of either C3H/He (gray) or ashen (black) mice and was represented by (F0–F)/F0, where F0 and F stand for resting and fluorescence and fluorescence after 20 mM glucose stimulation, respectively. Mean values are shown (n = 4).
