Table 4.
Preeclampsia associated WGCNA modules: For each module the annotated metabolites, the number of within module genes they are associated with and the biological processes these genes are enriched for are shown
| Module | Metabolites | Enriched Gene Ontology Processes |
|---|---|---|
| Black | (+/−)-trans- and cis-4,8-Dimethyl-3,7-nonadien-2-ol; (ent-2b,4S,9a)-2,4,9-Trihydroxy-10(14)-oplopen-3-one 2-(2-methylbutanoate) 9-(3-methyl-2E-pentenoate); 1-Methyl-2-pyrrolecarboxaldehyde; 13-Carboxy-gamma-tocopherol; 13-Hydroxy-gamma-tocopherol; 2-Deoxycastasterone; 2-Phenylethyl octanoate; 2,4-Dimethylpyridine; 5,8,11-Eicosatrienoate; 6-Deoxocastasterone; 6alpha-Hydroxycastasterone; 9-POHSA; multiple Sphingomyelins; C38:8 PC; Ganoderiol C; Momordol; Notoginsenoside R10; Pelletierine; Prostaglandin E2; tetradecyl sulfate; Tetrahydrocortisol; Trihydroxycoprostanoate; Tyramine; Uracil; xi-4,5-Dihydro-2,4(5)-dimethyl-1H-imidazole |
n=99 genes detection of chemical stimulus involved in sensory perception of taste negative regulation of viral genome replication benzene-containing compound metabolic process regulation of viral genome replication arginine catabolic process to proline arginine catabolic process to proline via ornithine extracellular amino acid transport extracellular transport TORC1 signaling mitochondrial mRNA 3′-end processing |
| Green | Bergaptol |
n=5 genes regulation of complement activation, alternative pathway negative regulation of complement activation, alternative pathway regulation of complement activation, classical pathway negative regulation of complement activation, classical pathway protein C-linked glycosylation via 2′-alpha-mannosyl-L-tryptophan protein C-linked glycosylation via tryptophan peptidyl-tryptophan modification protein C-linked glycosylation negative regulation of humoral immune response mediated by circulating immunoglobulin regulation of humoral immune response mediated by circulating immunoglobulin |
| Yellow | GABA |
n=43 genes platelet degranulation regulated exocytosis exocytosis secretion by cell regulation of leukocyte migration regulation of hemostasis regulation of blood coagulation regulation of coagulation regulation of cell motility secretion |
| Brown | (2E,6E)-2,6-Nonadienal; (Z)-5-[(5-Methyl-2-thienyl)methylene]-2(5H)-furanone; 1-(10-methylhexadecanyl)-2-(8-[3]-ladderane-octanyl)-sn-glycerophosphocholine; 1-Octene; 1-Stearoylglycerophosphoglycerol; 13-HOTE; 16-alpha-Hydroxypregnenolone; 2-Ethyl-4-methyloxazole; 2-Keto-6-aminocaproate; 2-Keto-6-aminocaproate; 3-Hydroxy-10-apo-b,y-carotenal; 35S-Methylokadaic acid 7-hexadecanoate; 4-oxo-Retinoic acid; 5-(10-Nonadecenyl)-1,3-benzenediol; 5-Hydroxyisourate; 7-Ethoxy-4-methyl-2H-1-benzopyran-2-one; 9-Carboxymethoxymethylguanine; Allitridin; Allodesmosine; Artemoin A; Biliverdin; multiple Lysophosphatidylcholines; multiple choline esters; multiple ceremides; multiple mono-, di- and tri-acylglycerols; multiple phosphatidylcholines; multiple phosphatidylinositol; multiple phosphatidylethanolamines; multiple phosphoserines; Caprate; Caprylic acid; Chloramphenicol; Chlormezanone; Cohibin A/C; Dimethamine; fructose/glucose/galactose; Furaneol; Isovalerylalanine; L-2-Amino-3-methylenehexanoic acid; Lutein; m-Chlorohippurate; Mabioside D; Montecristin; N-Nitroso-3-hydroxypyrrolidine; N-Phenylacetylphenylalanine; PGP(18:0/22:5(4Z,7Z,10Z,13Z,16Z)); Phenylethylamine; Quinoline; Saccharin; Sertaconazole; Sphingosine 1-phosphate (d16:1-P); Taurocyamine; Terpenyl isovalerate; Terpinolene oxide; Terpinyl isobutyrate; Triclosan |
n=792 genes defense response immune response inflammatory response innate immune response response to stress immune system process response to other organism response to external biotic stimulus response to biotic stimulus cellular response to other organism |
WGCNA – weighed gene co-expression correlation analysis