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The fixed effects meta-analysis model (Mantel-Haenszel method) was used for RFS A. and PFS B. while the random-effects model (Mantel-Haenszel method) was used for OS C.. Each trial is represented by a square, the center of which gives the HR for that trial. The size of the square is proportional to the information provided by the trial report. The ends of the horizontal bars denote the 95% CI.
