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Effect of interdomain interface mutations on ATP/substrate-bound DnaK* Cys333-Cys410 as measured by DEER
| DnaK* Cys333-Cys410 | Percentage undockeda | Effect on NBD/SBD interface |
|---|---|---|
| No mutation | 76 | |
| L390V | 60 | Stabilization |
| L454I | 68 | Stabilization |
| D481N | 82 | Destabilization |
a Percentages were calculated as the ratio of the area of peaks identified as undocked conformers divided by the total area of all peaks, based on the curves shown in Fig. 5.
