Table 10.
Mean PK parameters after a single 5 mg/kg intravenous and subcutaneous administration of control and arabinosylated mAb-1 in Sprague Dawley rats.
| Intravenousa |
Subcutaneousa |
|||||
|---|---|---|---|---|---|---|
| Sample | T1/2b (day) | CL (mL/h/kg) | Vss(mL/kg) | T1/2b (day) | Cmax (μg/mL) | F (%) |
| Control (n = 5) | 11.8 +/− 2.0 | 0.23 +/− 0.01 | 88.8 +/− 11.6 | 11.7 +/− 1.4 | 41.1 +/− 8.7 | 78.6 +/− 21.4 |
| + D-Arabinose (n = 5 IV, n = 3 SC) | 14.7 +/− 1.5 | 0.11 +/− 0.02 | 55.1 +/− 10.6 | 11.1 | 58.9 +/− 9.7 | 58.3 +/− 6.6 |
a
All numbers represent mean +/− 1 SD
b
Harmonic mean