Table 2.
Patient Characteristics
| ID | Sex | Age (years) | Primary Lesion | Resectiona | Differentiation | Metastasis | Lesion Numberb | Largest Size (cm)c | Prior Chemotherapy | Other Agents | Latest Evaluationd | Living Interval (months)e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 61 | sigmoid | Y | median | liver | >10 | 13.4 | XELOX | N | PD | 14 |
| 2 | M | 37 | transverse colon | Y | median | liver, LN | 1 | 4.5 | FOLFOX | N | PD | 19 |
| 3 | M | 70 | rectum | N | median | liver, lung, LN | >10 | 4.8 | XELOX, FOLFOX, XELIRI, bevacizumab | CIK | stable disease | 21 |
| 4 | M | 69 | rectum | Y | low | liver, lung, LN | >10 | 8.2 | FOLFOX6, FOLFORI | radiotherapy | PD | 21 |
| 5 | M | 68 | sigmoid | Y | median | liver, RAG, LN | 2 | 9.2 | FOLFOX, FOLFORI, Xeloda | radiotherapy | PD | 22 |
| 6 | F | 51 | ileocecumf | N | median | enterocoelia | extensive | 6.8 | FOLFORI, bevacizumab | N | PD | 6 |
| 7 | M | 64 | rectum | Y | median | liver, lung | >10 | 2.4 | FOLFOX, FOLFORI, XELOX | N | PD | 37 |
| 8 | F | 37 | ascending colon | Y | median | vertebra, LN | 1 | NE | FOLFOX, MFOLFOX, XELOX, IRIS, bevacizumab, Xeloda | radiotherapy | stable disease | 16 |
| 9 | M | 48 | ascending colon | Y | median | liver, lung, LN | >10 | 10.8 | FOLFOX, XELOX, FOLFIRI, SOX | CIK, RF | PD | 77 |
| 10 | F | 55 | rectum | Y | median | liver, lung, anastomosis, LN | 9 | 1.9 | CAPEOX, Xeloda, bevacizumab | radiotherapy, RF | PD | 32 |
CIK, cytokine-induced killers; F, female; LN, lymph node; M, male; N, no; NE, lesions on the vertebrae and lymph nodes were not evaluable; RAG, right adrenal gland; RF, radiofrequency ablation on liver lesions; Y, yes.
Resection represents primary lesion resection.
Lesion numbers do not include primary lesion and lymph node lesions.
Largest size is long diameter of the largest metastatic lesion.
Living interval is months from the first diagnosis to CAR-T infusion.
Latest evaluation before enrollment.
Lesionectomy was canceled for P6 because of extensive abdominal metastasis found during surgery.