Table 2. Local, regional and distant recurrence rates and clinical outcomes according to age.
| < 40 years (n=289) | ≥ 40 years (n=1641) | p value | |
|---|---|---|---|
| Local recurrence, N (%) | 17 (6 %) | 88 (5 %) | |
| Site local recurrence, N (%) | |||
| Breast | 13 (76 %) | 57 (65 %) | |
| Chest wall | 4 (24 %) | 30 (34 %) | |
| Unknown | 0 (0 %) | 1 (1 %) | |
| Cumulative incidence of local recurrence at 5 years (95% Confidence Interval) | 3.9 (1.5-6.2) | 4.5 (3.5-5.6) | 0.82 |
| Regional recurrence, N (%) | 5 (2 %) | 37 (2 %) | |
| Site of regional recurrence, N (%) | |||
| Axilla | 3 (60 %) | 23 (62 %) | |
| Supraclavicular LN | 0 (0 %) | 9 (24 %) | |
| Intramammary LN | 2 (40 %) | 5 (14 %) | |
| Cumulative incidence of regional recurrence at 5 years (95%Confidence Interval) | 1.9 (0.2-3.5) | 1.8 (1.1-2.5) | 0.57 |
| Distant recurrence, N (%) | 49 (17 %) | 189 (12 %) | |
| Site of first distant recurrence, N (%) | |||
| Multiple sites | 17 (36 %) | 69 (37 %) | |
| Visceral | 8 (16 %) | 48 (25 %) | |
| LN (mediastinal, thoracic, cervical) | 8 (16 %) | 19 (10 %) | |
| Brain | 8 (16 %) | 25 (13 %) | |
| Bone | 7 (14 %) | 21 (11 %) | |
| Other | 1 (2 %) | 7 (4 %) | |
| Cumulative incidence of distant recurrence at 5 years (95% Confidence Interval) | 17.9 (13.2-22.5) | 11.0 (9.4-12.6) | <0.01 |
| 5 year DFS, median (95% Confidence Interval) | 75.3 (70.2-80.7) | 77.7 (75.6-79.8) | 0.94 |
| Median follow-up, month, median (range) | 76.1 (0.3-196.1) | 73.2 (0-201.1) | 0.53 |
DFS: disease free survival