Table 20-1.
Pooled Prevalence of Valvular Heart Disease From CARDIA, ARIC, and CHS Cohorts
| Age, y |
P Value for Trend | Frequency Adjusted to 2000 US Adult Population | |||||
|---|---|---|---|---|---|---|---|
| 18–44 | 45–54 | 55–64 | 65–74 | ≥75 | |||
| Participants, n | 4351 | 696 | 1240 | 3879 | 1745 | … | 209 128 094 |
| Male, n (%) | 1959 (45) | 258 (37) | 415 (33) | 1586 (41) | 826 (47) | … | 100 994 367 (48) |
| Mitral regurgitation (n=449), n (%) | 23 (0.5) | 1 (0.1) | 12 (1.0) | 250 (6.4) | 163 (9.3) | <0.0001 | 1.7% (95% CI, 1.5%–1.9%) |
| Mitral stenosis (n=15), n (%) | 0 (0) | 1 (0.1) | 3 (0.2) | 7 (0.2) | 4 (0.2) | 0.006 | 0.1% (95% CI, 0.02%–0.2%) |
| Aortic regurgitation (n=90), n (%) | 10 (0.2) | 1 (0.1) | 8 (0.7) | 37 (1.0) | 34 (2.0) | <0.0001 | 0.5% (95% CI, 0.3%–0.6%) |
| Aortic stenosis (n=102), n (%) | 1 (0.02) | 1 (0.1) | 2 (0.2) | 50 (1.3) | 48 (2.8) | <0.0001 | 0.4% (95% CI, 0.3%–0.5%) |
| Any valve disease, n (%) | |||||||
| Overall (n=615) | 31 (0.7) | 3 (0.4) | 23 (1.9) | 328 (8.5) | 230 (13.2) | <0.0001 | 2.5% (95% CI, 2.2%–2.7%) |
| Women (n=356) | 19 (0.8) | 1 (0.2) | 13 (1.6) | 208 (9.1) | 115 (12.6) | <0.0001 | 2.4% (95% CI, 2.1%–2.8%) |
| Men (n=259) | 12 (0.6) | 2 (0.8) | 10 (2.4) | 120 (7.6) | 115 (14.0) | <0.0001 | 2.5% (95% CI, 2.1%–2.9%) |
CARDIA indicates Coronary Artery Risk Development in Young Adults; ARIC, Atherosclerosis Risk in Communities study; CHS, Cardiovascular Health Study; and CI, confidence interval.
Source: Reprinted from Nkomo et al1 with permission of the publisher.