Figure 4.
Indirect effect of IL18 haplotype on mood and anxiety symptoms via amygdala reactivity in women. Indirect effect model is shown for women only; model is not shown for men because neither path was significant. The CG/CG IL18 haplotype group (individuals homozygous for the rs187238 major C allele and for the rs1946518 major G allele) evidenced increased left centromedial threat-related amygdala reactivity. Increased threat-related amygdala reactivity in turn predicted higher mood and anxiety symptoms under higher levels of recent life stress. The indirect effect of IL18 haplotype on mood and anxiety symptoms through amygdala reactivity was significant, but only in individuals reporting higher levels of life stress.