FIG. 3.
MyD88−/−, but not TLR2−/−, mice are more sensitive to killing, relative to wild-type mice, after i.p. challenge with live S. pneumoniae type 14. Naïve wild-type (C57BL/6 and 129B6), MyD88−/−, and TLR2−/− mice were inoculated i.p. with different doses of live S. pneumoniae type 14 and were monitored for survival. A separate group of mice were first challenged with heat-killed S. pneumoniae type 14 (2 × 108 CFU/mouse) i.p. and then rechallenged with live S. pneumoniae type 14 i.p. 3 weeks later. Results are from five (groups A, B, and D) and eight (group C) mice per group.