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Binding affinities of wild-type and mutant TDP-43
The apparent equilibrium dissociation constant Kd(app) measured for recombinant TDP-43 binding to A(GU)6 RNA.
| Kd(app) | |
|---|---|
| nm | |
| Wild-type | 2.3 ± 0.5 |
| ΔC (aa 1–261) | 2.8 ± 0.6 |
| RRM1–2 (aa 102–269) | 2.2 ± 0.5 |
| RRM1–2 W113A | NDa |
| RRM1–2 W113F | 6.0 ± 0.6 |
| RRM1–2 W172F | 2.0 ± 0.4 |
| RRM1–2 W172A | 5.0 ± 0.6 |
| F147/149L | NDa |
| T153A/Y155A | 3.1 ± 0.6 |
| T153E/Y155E | 10 ± 3 |
a ND, not determined.
