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. Author manuscript; available in PMC: 2017 Mar 31.
Published in final edited form as: Cancer Cell. 2016 Jul 14;30(2):324–336. doi: 10.1016/j.ccell.2016.06.003

Figure 6. High Expression of CCR7 Correlates with Greater T Cell Infiltration in Human Mela-noma and Better Patient Outcomes.

Figure 6

(A) Scatterplot showing CCR7 transcript levels from 44 human melanoma samples against the transcript levels of IRF8 and FLT3. Pearson correlation coeffi-cient is shown.

(B) Representative flow cytometric plots of CCR7 levels on tumor immune populations from a fresh human metastatic melanoma biopsy.

(C) Histogram showing CD3+ T cell counts from 44 human melanoma samples with less than median CCR7 expression (CCR7lo) or above median CCR7 expression (CCR7hi). T cells were counted on histo-logical slides by microscopy. Data are presented as mean ± SEM. **p < 0.01.

(D) Survival curve of melanoma patients stratified as in (C). Curves were analyzed using the Gehan-Bre-slow-Wilcoxon test.

See also Figure S4.