Figure 7.
Mediation analysis of pathological activation, Braak I/II tau, and cortical thickness. Mediation analysis with pathological activation (red), mediated by Braak I/II AV-1451 standard uptake volume ratio (blue), predicting right entorhinal cortical thickness (green) are shown. Pathological activation positively predicted Braak I/II AV-1451, Braak I/II AV-1451 negatively predicted entorhinal cortical thickness, which resulted in a significant mediation. Numerical values are regression coefficients (β) from models controlling for age, sex, and education. See text for more details. *p < 0.05.