Figure 4. Pleiotropy-informed ALS risk loci determined by analysis of cFDR in ALS GWAS P-values given schizophrenia GWAS P-values (cFDRALS|SCZ).
Each point denotes a SNP; its x axis position corresponds to its chromosomal location and its height indicates the extent of association with ALS by cFDR analysis. The solid line indicates the threshold cFDR=0.01. Any gene whose role in ALS is already established is in bold. A complete list of all loci at cFDR⩽0.05 is provided in Supplementary Table 8.
