Figure 4. PS expressing exosomes in blood are a cancer biomarker.
A. Standard curve generated from the indicated amounts of PS expressed on the outer leaflet of LUV generated from PS/PC (wt/wt) (solid circles) and PC alone (open circles). For the 100% PC control vesicles, the total amount of added phospholipid was 4X the amounts indicated on the abscissa for PS. B. PS-expressing tumor exosomes in patient plasma. C. Patient CA-125 levels. ROC plots for PS for benign vs normal D., malignant vs benign E. and CA-125 plot for malignant vs benign F.