Figure 3.
Circulating exosomes modulate co-stimulatory molecules on antigen-presenting cells in PBC. Freshly isolated 1 × 106 PBMCs were cultured with or without autologous circulating exosomes for 16 h. The expression of co-stimulatory and major histocompatibility complex (MHC)-II molecules on CD14+ monocytes, CD11c+ DCs, and CD19+ B cells in PBC (n = 14) were compared with HC (n = 12) by mean fluorescent intensity. The numbers indicate the P-values of MFI between groups of cells cultured with medium alone (Med) and exosomes (Exo).P-values were calculated by a two-tailed paired t-test.