Table 1. High PIP4K2B expression correlates with ERBB2 expression and low PIP4K2B expression associates with worse clinical parameter.
Correlation between PIP4K2B staining and clinico-pathological and molecular parameters of advanced breast cancer. Significant P values are marked in bold.
| PIP4K2B | P-Chi-Sq | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Variable and categories | 1 | 2 | 3 | Total | P | |
|
| ||||||
| Her 2 | 0 | 188 | 151 | 58 | 397 | 0.000 |
| 2+ | 10 | 13 | 11 | 34 | ||
| 3+ | 15 | 18 | 16 | 49 | ||
| Median age (range) | 65(28-92) | 65(27-96) | 63(34-90) | |||
| 221 | 183 | 85 | 489 | 0.165 | ||
| Nhg | 1 | 43 | 57 | 22 | 122 | 0.007 |
| 2 | 91 | 68 | 44 | 203 | ||
| 3 | 87 | 57 | 19 | 163 | ||
| Size (median) | 19 | 15 | 15 | |||
| 221 | 183 | 85 | 489 | 0.021 | ||
| Lymph node status | 0 | 117 | 109 | 49 | 275 | 0.375 |
| 1 | 79 | 59 | 23 | 161 | ||
| ki67 | 0-10 | 65 | 76 | 34 | 175 | 0.011 |
| 11-25 | 67 | 60 | 28 | 155 | ||
| >25 | 74 | 38 | 16 | 128 | ||
| ER | 0 | 37 | 19 | 13 | 69 | 0.174 |
| 1 | 181 | 161 | 71 | 422 | ||
| PR | 0 | 53 | 30 | 17 | 102 | 0.332 |
| 1 | 162 | 146 | 67 | 375 | ||
| Tumour type | Ductal | 139 | 122 | 63 | 324 | |
| Lobular | 33 | 26 | 11 | 70 | ||
| Distant metastasis | no | 113 | 115 | 53 | 281 | 0.040 |
| during follow-up | yes | 52 | 23 | 13 | 88 | |
| unknown | 54 | 43 | 19 | 116 | ||