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. 2004 Oct 15;18(20):2474–2478. doi: 10.1101/gad.1239004

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Figure 4. — Loss of arterial identity in Dll4^-/- endothelial cells. In situ hybridization (A-F) and immunostaining (G-J) of adjacent cryosections from E9.0 embryos. (A,B) Flk-1 mRNA is present in the endothelial cells of both dorsal aorta (da) and anterior cardinal vein (acv). (C,F) Endothelial cells in Dll4^-/- embryos fail to express arterial-specific EphrinB2 (Efnb2) and Connexin37 (Cx37) mRNAs. (G-J) The endothelial cells (shown by PECAM immunostaining in G,H) lining the dorsal aortae in Dll4^-/- embryos express the venous-specific EphB4 receptor; notice also the fusion between the dorsal aorta and the anterior cardinal vein on the right side of the picture (J).