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Signaling pathways affected in CD and UC. Genes recurrently mutated or amplified were assigned to manually curated pathways based on KEGG, Gene Ontology, Pathway Commons, and Ingenuity Pathway Analysis (IPA Ingenuity Systems, http://www.ingenuity.com). Pathways for discussion were selected based on prior association with CRC or the presence of multiple recurrently mutated genes in the pathway.
