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Retrospective neuropathological validation of RT QuIC.
| Neuropathological Assesment | ||||||
|---|---|---|---|---|---|---|
| CSF | Unit | Prion Negative |
Prion Positive |
sCJD | gCJD | |
| RT QuIC | n | 67 | 126 | 111 | 15 | |
| Specificity | % | 98.5 | 98.5 | 98.5 | ||
| Sensitivity | % | 92.1 | 91.9 | 93.3 | ||
| PPV | % | 99.1 | 99.0 | 93.3 | ||
| NPV | % | 86.8 | 88.0 | 98.5 | ||
| 14-3-3 | ||||||
| Specificity | % | 62.7 | 62.7 | 62.7 | ||
| Sensitivity | % | 81.7 | 82.9 | 73.3 | ||
| PPV | % | 81.1 | 79.3 | 31.4 | ||
| NPV | % | 82.4 | 87.5 | 93.3 | ||
| tTau≥1150 pg/ml | ||||||
| Specificity | % | 46.3 | 46.3 | 46.3 | ||
| Sensitivity | % | 90.5 | 91.0 | 86.7 | ||
| PPV | % | 76.0 | 73.7 | 26.5 | ||
| NPV | % | 72.1 | 75.6 | 93.9 | ||
