| Genes related to environment, nutrition, and redox |
418 |
884 |
General (SOD1). Nutrition response and metabolism-related [hexokinase 1; high-glucose-regulated protein 8 (HGRG8); fatty acid desaturase 1, 2, 3 (FADS1, FADS2, FADS3); phosphoglycerate kinase 1 (PGK1); hydroxysteroid (11-β) dehydrogenase 2 (HSD11B2); cytochrome P450 family (2, 3, 4, 11, 17, 19, 20, 21); S-adenosylhomocysteine hydrolase (AHCY); methylenetetrahydrofolate dehydrogenase (MTHFD1); AK2, AK3; adenosine deaminase (ADAR); cytoskeleton-related vitamin A responsive protein (JWA)]. Hormone regulation [corticotropin-releasing hormone (CRH); glucocorticoid modulatory element binding protein 1 (GMEB1); Adrenomedullin (ADM); prolactin regulatory element-binding protein (PREB); cytosolic thyroid hormone-binding protein (pyruvate kinase, muscle); gastrin-binding protein (HADHA, HADHB)]. ATP synthesis and ATPase (ATP5A1; ATP5B; ATP5F1; ATP5G2). Oxidation and electron transfer [flavoprotein (ETFB); flavoprotein dehydrogenase (ETFDH); NADH dehydrogenase (NDUFV1); P450 cytochrome oxidoreductase]. Glutathione-related [glutathione S-transferase (GST) A2, π; glutathione synthetase; glutathione peroxidase 1, 3, 4; γ-glutamyltransferase-like activity 1 (GGTLA1); glyceronephosphate O-acyltransferase (GNPAT)] |
| Immune response related |
101 |
265 |
Cytokine/chemokines [interferon γ; interferon β 2 (IL6); chemokine (C-X3-C motif) ligand 1; chemokine (C-X-C motif) ligand 2; thymosin β 10]. Cytokine/chemokine receptors (CSF2RB; CSF3R). Interleukin receptors (IL1RL1; IL2RB; IL4R; IL10RA; IL17R). Cytokine-induced or regulatory proteins [interferon γ inducible protein 30 (IFI30); interferon-induced tetratricopeptide IFI60 (IFIT4); interferon-induced cellular resistance mediator M×A (MX 1)]. Antigen-related proteins [B cell receptor-associated protein 31 (BCAP31); antigen NY-CO-43 (PRKWNK2); CD4; CD44; hepatocellular carcinoma-associated antigen 59,66; squamous cell carcinoma antigen (SART1, 3); MAGED 1, 2, 4; melanoma 1 antigen (CD63); melanoma-associated gene (D2S448)]. Immune response modulatory proteins [Defensin α 1; decay accelerating factor (DAF); NK cell activating factor (PRG2)] |
| Ion channels, transporters, and exchangers |
111 |
222 |
Ion channels [chloride channel 7 (CLCN7); sodium channel (SCN5A); potassium channel (KCNK3); calcium channel β 3 subunit (CACNB3); vacuolar H+ATPase subunit V0 (ATP6V0D1)]. Transporters and related proteins [anion exchanger (SLC4A1); potassium/chloride transporters (SLC12A4); sodium/hydrogen exchanger regulator factor 1, 2 (SLC9A3R1, SLC9A3R2); organic cation transporter (SLC22A1L, SLC22A1); amino acid transporter 4, 7 (SLC7A4, SLC7A7); facilitated glucose transporter (SLC2A8)] |
| Other proteins related to systemic regulation |
20 |
30 |
PER1; Timeless Clock; NMDA R 2C (GRIN2C); GABARAP; GABARAPL; nicotinic acetylcholine R (CHRNB4); folate R 2 (FOLR2); opioid growth factor receptor (OGFR); ciliary neurotrophic factor receptor (CNTFR); GDNF family receptor α 1, 2 (GFRA 1, 2); sphingolipid G-protein-coupled receptor 5 (EDG5) |
